This link contains instructions for how to set preferences for Microsoft Defender for Endpoint on macOS in enterprise organizations. To configure Microsoft Defender for Endpoint on macOS using the command-line interface, see Resources.
Manual Client Configuration
https://learn.microsoft.com/en-us/microsoft-365/security/defender-endpoint/mac-install-manually?view=o365-worldwide#application-installation-macos-11-and-newer-versions
Microsoft Defender for Endpoint for Mac – New Command Line Syntax
https://community.jamf.com/t5/jamf-pro/microsoft-defender-for-endpoint-for-mac-new-command-line-syntax/td-p/229110